C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7125 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C12Q 1/44 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2366408
The invention relates to the inhibition of histone deacetylase expression and enzymatic activity and, in particular, to the inhibition of a specific histone deacetylase. The invention also relates to compositions comprising antisense oligonucleotides and methods of using the same to inhibit a histone deacetylase. Also disclosed are methods for identifying a histone deacetylase involved in induction of cell proliferation, and methods for identifying compounds that interact with and reduce the enzymatic activity of such a histone deacetylase.
L'invention concerne l'inhibition de l'expression et de l'activit~ enzymatique d'histone d~ac~tylase et, en particulier, l'inhibition d'une histone d~ac~tylase sp~cifique. L'invention concerne ~galement des compositions comprenant des oligonucl~otides antisens, ainsi que des proc~d~s d'utilisation de celles-ci pour inhiber une histone d~ac~tylase. Enfin, l'invention concerne ~galement des proc~d~s permettant d'identifier une histone d~ac~tylase intervenant dans l'induction de la prolif~ration cellulaire, ainsi que des proc~d~s permettant d'identifier des compos~s qui r~agissent mutuellement avec l'activit~ enzymatique d'une telle histone d~ac~tylase et r~duisent cette activit~.
Besterman Jeffrey M.
Li Zuomei
Macleod Alan R.
Methylgene Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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