Inhibition of hiv-1 replication by antisense rna expression

Details Inhibition of hiv-1 replication by antisense rna expression Inhibition of hiv-1 replication by antisense rna expression

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 35/28 (2006.01) A61K 48/00 (2006.01) C07K 14/16 (2006.01) C12N 5/10 (2006.01) C12N 15/49 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2254819

Novel antisense sequences to the unspliced or single spliced portions of mRNA transcript from HIV-1 provirus, optionally co-expressed with an inhibitory transdominant mutant HIV-1 protein, are found to be useful in the treatment of HIV-1 infection.

L'invention concerne des nouvelles séquences antisens ayant pour cible des portions à épissage simple ou non épissées d'un produit de transcription d'ARNm provenant du provirus du VIH de type 1 (VIH-1), éventuellement exprimées en même temps qu'une protéine du VIH-1 mutante, transdominante et inhibitrice. Ces séquences sont utiles dans le traitement de l'infection à VIH-1.

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