Inhibition of hiv using synergistic combinations of...

Details Inhibition of hiv using synergistic combinations of... Inhibition of hiv using synergistic combinations of...

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 31/505 (2006.01) A61K 31/52 (2006.01) A61K 39/21 (2006.01) A61K 45/06 (2006.01) C07D 405/04 (2006.01) C07D 473/30 (2006.01) C07D 473/34 (2006.01) C07H 19/00 (2006.01) C07H 19/04 (2006.01) C07H 19/06 (2006.01) C07H 19/16 (2006.01) C12N 7/00 (2006.01) C12N 7/06 (2006.01) C12N 9/00 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2050473

ABSTRACT The present invention relates to the use of synergistic combinations of nucleoside derivatives for inhibiting human immunodeficiency virus (HIV) replica- tion, thereby limiting HIV infection. In a particular embodiment, the purine nucleoside analogue dideoxyino- sine combined with the pyrimidine nucleoside analogue 2',3'-dideoxy-2',3'-didehydrothymidine (d4T) exhibit strong synergistic activity and diminished cytotoxic activity toward mammalian cells.

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