Inhibition of human immunodeficiency virus (hiv-1) replication

Details Inhibition of human immunodeficiency virus (hiv-1) replication Inhibition of human immunodeficiency virus (hiv-1) replication

C - Chemistry, Metallurgy

12

N

C12N 15/63 (2006.01) A61K 48/00 (2006.01) C12N 9/00 (2006.01) C12N 9/12 (2006.01) C12N 15/85 (2006.01) C12N 15/86 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2306444

The present invention is directed to an HIV-1-regulated antiviral system. The invention provides constructs and methods for transferring an antiviral enzyme into target cells, wherein the enzyme is under HIV-1 regulation. HIV-1 infection of the targeted cells causes the activation of the antiviral enzyme, and results in the inhibition of viral replication. The HIV-1 controlled antiviral approach can be combined with traditional chemotherapeutic approaches, permitting a significant reduction in antiviral drugs, with decreased side effects, and the maintenance of HIV-1 in a true latent state.

Cette invention se rapporte à un système antiviral avec régulation du VIH-1. Cette invention propose des produits de synthèse et des procédés permettant de transférer une enzyme antivirale dans des cellules cibles, où cette enzyme se trouve soumise à une régulation du VIH-1. L'infection par VIH-1 de ces cellules cibles entraîne l'activation de l'enzyme antivirale et aboutit à l'inhibition de la réplication virale. Cette approche antivirale contre le VIH-1 peut être combinée avec des approches chimiothérapeutiques traditionnelles, ce qui permet de réduire considérablement l'utilisation des médicaments antiviraux, avec une baisse des effets secondaires qui les accompagnent, et de maintenir le VIH-1 dans un état latent réel.

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