Inhibition of ii expression in mammalian cells

Details Inhibition of ii expression in mammalian cells Inhibition of ii expression in mammalian cells

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61K 35/12 (2006.01) A61K 39/00 (2006.01) C12N 5/10 (2006.01) C12N 5/12 (2006.01) C12N 15/11 (2006.01) C12N 15/86 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2482993

The present invention is directed toward composition and methods involving the inhibition of Ii expression in cells for the purpose of altering antigen presentation pathways. More specifically, disclosed are compositions and methods which relate to MHC Class II molecule presentation of antigenic epitopes which, under normal circumstances, would not be presented in association with MHC Class II molecules. The invention relates to presentation in cells which normally express MHC Class II molecules, as well as cells which can be induced to express MHC Class II molecules.

L'invention se rapporte à des compositions et à des procédés impliquant l'inhibition de l'expression de Ii dans des cellules en vue d'altérer des voies de présentation antigénique. L'invention concerne de manière plus spécifique des compositions et des procédés concernant la présentation, par les molécules de classe II du CMH, de déterminants antigéniques qui, dans des circonstances normales, ne seraient pas présentés en association avec les molécules de classe II du CMH. L'invention se rapporte en outre au processus de présentation chez des cellules qui expriment normalement les molécules de classe II du CMH, ainsi que des cellules dont l'expression de molécules de classe II du CMH peut être induite.

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