A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/18 (2006.01)
Patent
CA 2636909
Provided are methods of attenuating release of a proinflammatory cytokine from a mammalian cell. Also provided are methods of inhibiting or treating an inflammatory cytokine cascade in a mammal. Further provided are methods of treating a mammal at risk for or undergoing sepsis, septicemia, and/or endotoxic shock. Additionally provided are methods of attenuating NO release from a mammalian cell. Also provided are methods of attenuating NO production in a mammal at risk for, or having, a disorder mediated by excessive NO production.
La présente invention concerne des procédés permettant d~atténuer la libération d~une cytokine pro-inflammatoire par des cellules chez un mammifère. L~invention concerne également des procédés permettant d~inhiber ou de traiter une cascade de cytokine inflammatoire chez un mammifère ; des procédés visant à traiter un mammifère susceptible de subir ou subissant un risque de sepsie, de septicémie et/ou de choc endotoxique ; des procédés visant à atténuer la libération de NO par des cellules chez un mammifère ; et enfin des procédés visant à atténuer la production de NO chez un mammifère susceptible d~être atteint ou étant atteint par un trouble dû à une production excessive de NO.
Chen Dazhi
Sama Andrew E.
Wang Haichao
Osler Hoskin & Harcourt Llp
The Feinstein Institute For Medical Research
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