Inhibition of influenza virus replication by oligonucleotides

Details Inhibition of influenza virus replication by oligonucleotides Inhibition of influenza virus replication by oligonucleotides

A - Human Necessities

61

K

A61K 31/70 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/70 (2006.01)

Patent

CA 2081777

2081777 9116902 PCTABS00008 A method of inhibiting influenza virus replication through the activity of natural (unmodified) or modified oligonucleotides (oligodeoxynucleotides or oligoribonucleotides) which hybridize to a selected region of the influenza virus RNA and interfere with its ability to serve as a template for synthesis of encoded products. Oligonucleotides (unmodified or modified) which have antiviral activity against influenza virus as a result of their ability to hybridize to a selected region of influenza virus RNA and inhibit its ability to serve as a template for synthesis of encoded products, as well as compositions which include the oligonucleotides.

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