Inhibition of intermediate-conductance calcium activated...

Details Inhibition of intermediate-conductance calcium activated... Inhibition of intermediate-conductance calcium activated...

A - Human Necessities

61

K

A61K 31/415 (2006.01)

Patent

CA 2620923

Methods for treating or preventing atherosclerosis in human or non-human animal subjects by inhibiting or blocking intermediate-conductance calcium activated potassium channels associated with vascular smooth muscle and/or other cells which play a role in the pathogenesis of atherosclerosis (e.g., KCa3.1, KCNN4, IKCa1, IK1, SK4 channels).

L'invention concerne des méthodes permettant de traiter ou de prévenir l'athérosclérose chez des sujets humains ou des animaux non humains par inhibition ou blocage de canaux potassiques activés par le calcium de conductance intermédiaire associés à un muscle lisse vasculaire et/ou à d'autres cellules qui jouent un rôle dans la pathogénèse de l'athérosclérose (par exemple, les canaux KCa3.1, KCNN4, IKCa1, IK1, SK4).

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