Inhibition of liver cancer by the use of gnrh and gnrh analogs

A - Human Necessities – 61 – K

Patent

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Details

A61K 38/09 (2006.01) C07K 7/23 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2189326

The invention provides a method for treating liver cancer in a mammal comprising administering to the mammal an inhibitory effective amount of at least one GnRH-related compound. Pharmaceutical preparations useful for the treatment of liver cancer comprising an inhibitory effective amount of at least one GnRH-related compound and a pharmaceutically acceptable carrier are also provided. A further aspect of the invention provides a method for diagnosing liver cancer by determining the presence of receptors for GnRH on a biological sample.

L'invention concerne un procédé de traitement du cancer du foie chez un mammifère consistant à administrer à un mammifère une dose inhibitrice efficace d'au moins un composé apparenté à la gonadolibérine (GnRH). L'invention permet d'obtenir des préparations pharmaceutiques destinées à être utilisées dans le traitement du cancer du foie et comprenant une dose inhibitrice efficace d'au moins un composé apparenté à la gonadolibérine et d'un excipient pharmaceutiquement acceptable. Un autre aspect de l'invention concerne un procédé permettant d'établir le diagnostic du cancer du foie grâce à la détermination de la présence de récepteurs de la gonadolibérine dans un échantillon biologique.

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