Inhibition of macrophage-stimulating protein receptor (ron)...

Details Inhibition of macrophage-stimulating protein receptor (ron)... Inhibition of macrophage-stimulating protein receptor (ron)...

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2706583

The invention provides antibodies or fragments thereof, including human antibodies, specific for Macrophage- Stimulating Protein Receptor (MSP-R or RON), which inhibit RON activation. Also provided are methods to inhibit RON, particularly the use of RON antibodies to treat diseases such as cancer.

L'invention concerne des anticorps ou des fragments de ceux-ci, comprenant des anticorps humains, spécifiques du récepteur de la protéine stimulant les macrophages (MSP-R ou RON), qui inhibent l'activation de RON. L'invention conceren également des procédés permettant d'inhiber RON, en particulier l'utilisation d'anticorps RON pour le traitement de maladies telles que le cancer.

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