Inhibition of mammalian muscle wasting and protein...

Details Inhibition of mammalian muscle wasting and protein... Inhibition of mammalian muscle wasting and protein...

A - Human Necessities

61

K

A61K 31/65 (2006.01)

Patent

CA 2045885

A method for treating mammals suffering from skeletal muscle wasting and/or intracellular protein degradation of skeletal muscle systems by administering to the mammal an amount of tetracycline which results in a significant reduction of the muscle wasting and protein degradation is disclosed. In addition, there is also disclosed a method of increasing the protein content of skeletal muscle systems of mammals by administration of tetracyclines. The tetracyclines useful in the above methods are both antimicrobial and non-antimicrobial. In a preferred embodiment, the method of treatment utilizes a non-antimicrobial tetracycline such as dedimethylamino- tetracycline (CMT).

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