C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 15/08 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) C08B 37/00 (2006.01)
Patent
CA 2089375
2089375 9204048 PCTABS00011 Agents and methods for inhibiting metastasis potential of tumor cells are provided. Metastasis potential of tumor cells may be inhibited by an agent selected from the group consisting of (a) tumor-associated carbohydrate antigens (TACAs) that exhibit differential prognostic significance, (b) antibodies that specifically bind to these antigens, (c) oligosaccharide components of these antigens, and (d) conjugates of these antigens or oligosaccharides, wherein the agent inhibits the metastasis potential of the preparation. Additional oligosaccharides for use within the methods and compositions provided herein include lactose and lactose derivatives. The present invention also discloses conjugates comprising oligosaccharides and poly(ethylene glycol).
Hakomori Senitiroh
Toyokuni Tatsushi
Biomembrane Institute (the)
G. Ronald Bell & Associates
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