Inhibition of microtubule protrusion in cancer cells

Details Inhibition of microtubule protrusion in cancer cells Inhibition of microtubule protrusion in cancer cells

A - Human Necessities

61

K

A61K 31/713 (2006.01) A61K 31/404 (2006.01) A61K 31/427 (2006.01) A61P 35/04 (2006.01) G01N 33/50 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2645095

The present invention generally concerns microtubule protrusions in cancer cells, including detached cancer cells, and inhibition of the protrusions. In particular aspects, the inhibition of the protrusions interferes with attachment of the cell to a vessel wall, and in further aspects the cell is killed by forcing it to enter capillaries and be destroyed, for example by shearing. Inhibition by a variety of agents and methods is contemplated.

La présente invention concerne en général des protrusions de microtubules dans des cellules cancéreuses, dont des cellules cancéreuses distinctes et l'inhibition des protrusions. Dans des aspects particuliers, l'inhibition des protrusions interfère avec la fixation de la cellule à la paroi d'un vaisseau, et dans d'autres aspects, la cellule est tuée en la forçant à pénétrer dans des capillaires et à être détruite, par exemple par cisaillement. La présente invention concerne l'inhibition par une variété d'agents et de procédés.

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