Inhibition of mitogen-activated protein kinase (mapk)...

Details Inhibition of mitogen-activated protein kinase (mapk)... Inhibition of mitogen-activated protein kinase (mapk)...

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/166 (2006.01) A61K 31/275 (2006.01) A61K 31/352 (2006.01) A61K 38/45 (2006.01)

Patent

CA 2419567

Inhibitors of the MAPK pathway, including MEK-directed proteases and small molecule inhibitors, are cytotoxic to human melanoma cells in vitro and in vivo via apoptotic mechanisms. These compounds are used to kill melanoma cells and to treat subjects with melanoma, either alone or in combination with other therapeutic modalities.

Des inhibiteurs de la voie de la protéine MAPKKK, notamment des protéases spécifiques de MEK et des inhibiteurs de petite molécule, ont une action cytotoxique à l'encontre de cellules humaines de mélanome, in vitro et in vivo, par le biais de mécanismes apoptotiques. On utilise ces composés, seuls ou associés à d'autres protocoles thérapeutiques, pour tuer des cellules de mélanome ainsi que pour traiter des sujets atteints de mélanome.

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