A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 33/24 (2006.01) A61P 17/00 (2006.01) A61P 27/02 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)
Patent
CA 2723480
The present invention provides methods for reducing, reversing or inhibiting neovascularization in a tissue of a mammalian subject having a pathological condition involving neovascularization by administration in vivo of nanoceria particles (cerium oxide nanoparticles) to the subject. The method of the invention is useful, for example, for reducing, treating, reversing or inhibiting neovascularization in ocular tissue such as the retina, macula or cornea; in skin; in synovial tissue; in intestinal tissue; or in bone. In addition, the method of the invention is useful for reducing or inhibiting neovascularization in a neoplasm (tumors), which can be benign or malignant and, where malignant, can be a metastatic neoplasm. As such, the invention provides compositions, which contain nanoceria particles and are useful for reducing, treating, reversing or inhibiting angiogenesis in a mammalian subject.
La présente invention concerne des procédés pour réduire, inverser ou inhiber la néovascularisation dans un tissu d'un sujet mammifère dont l'état pathologique implique une néovascularisation par administration in vivo au sujet de nanoparticules d'oxyde de cérium. Le procédé selon l'invention est utile, par exemple, pour réduire, traiter, inverser ou inhiber la néovascularisation d'un tissu oculaire, comme la rétine, la macule ou la cornée, de la peau, du tissu synovial, du tissu intestinal, ou de l'os. En outre, le procédé selon l'invention est utile pour réduire ou inhiber la néovascularisation dans un néoplasme (tumeurs), qui peut être bénin ou malin, et, s'il est malin, qui peut être un néoplasme métastasique. Ainsi, l'invention propose des compositions qui contiennent des nanoparticules d'oxyde de cérium et qui sont utiles pour réduire, traiter, inverser ou inhiber l'angiogenèse chez un mammifère sujet.
Mcginnis James F.
Seal Sudipta
Wong Lily L.
Zhou Xiaohong
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
The Board Of Regents Of The University Of Oklahoma
University Of Central Florida Research Foundation
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