Inhibition of neovascularization using vegf-specific...

Details Inhibition of neovascularization using vegf-specific... Inhibition of neovascularization using vegf-specific...

A - Human Necessities

61

K

A61K 31/7125 (2006.01) A61K 31/70 (2006.01) A61K 31/7088 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2210998

Disclosed are methods of reducing neovascularization and of treating various disorders associated with neovascularization. These methods include administering to a tissue or subject a synthetic oligonucleotide specific for vascular endothelial growth factor nucleic acid effective in inhibiting the expression of vascular endothelial growth factor.

L'invention concerne des procédés d'inhibition de la néoformation de vaisseaux sanguins et de traitement de troubles divers associés à la néoformation de vaisseaux sanguins. Ces procédés consistent à administrer à un tissu ou à un sujet un oligonucléotide synthétique spécifique de l'acide nucléique du facteur de croissance endothélial vasculaire (VEGF) inhibant efficacement l'expression du facteur de croissance endothélial vasculaire.

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