Inhibition of nf-.kappa.b by triterpene compositions

Details Inhibition of nf-.kappa.b by triterpene compositions Inhibition of nf-.kappa.b by triterpene compositions

A - Human Necessities

61

K

A61K 31/704 (2006.01) A61K 31/215 (2006.01) A61K 31/702 (2006.01) A61K 47/26 (2006.01) A61P 29/00 (2006.01)

Patent

CA 2429177

The invention provides methods for the inhibition of inflammation by providing, to a cell, in need thereof, monoterpene compositions that inhibit NF-.kappa.B. These compositions may also contain a carrier moiety that renders the monoterpene composition membrane permeable. The carrier may include triterpenoid moieties, sugars, lipids, or even additional monoterpenoid moieties. The composition can also contain additional chemical functionalites. Methods for using these compounds to prevent and treat a wide range of inflammatory conditions, especially, premalignant inflammatory conditions are described.

L'invention concerne des procédés visant à inhiber l'inflammation par l'apport, à une cellule nécessitant un tel traitement, de compositions de monoterpène qui inhibent NF-.kappa.B. Ces compositions peuvent aussi contenir une fraction transporteur qui rend perméable la membrane de la composition de monoterpène. Le transporteur peut comprendre des fractions triterpénoïdes, des sucres, des lipides ou même des fractions monoterpénoïdes supplémentaires. La composition peut également comporter des fonctionnalités chimiques supplémentaires. L'invention concerne aussi des procédés d'utilisation de ces composés pour prévenir et traiter un large éventail d'états inflammatoires, notamment des états inflammatoires prémalins.

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