Inhibition of osteolytic lesions by src kinase inhibitors

Details Inhibition of osteolytic lesions by src kinase inhibitors Inhibition of osteolytic lesions by src kinase inhibitors

A - Human Necessities

61

K

A61K 31/496 (2006.01) A61K 31/4709 (2006.01) A61P 19/08 (2006.01) A61P 35/04 (2006.01)

Patent

CA 2612333

The present invention include methods and compositions for treating bone- resorbing diseases or bone resorption related to a pathologic condition generally, including, but not limited to osteoporosis, arthritis, rheumatoid arthritis, cancer metastases to the bone, bone cancer, hypercalcemia, osteolytic lesions with orthopedic implants, Paget's disease, and bone loss associated with hyperparathyroidism. Representative cancers include, but are not limited to breast cancer, prostrate cancer, colon cancer, endometrial cancer, multiple myeloma, renal cell carcinoma, heck and neck cancers, and cervical carcinoma. Arthritic conditions include, but are not limited to adjuvant-, collagen-, bacterial- and antigen-induced arthritis, particularly rheumatoid arthritis.

Procédés et compositions pour le traitement de maladies à résorption osseuse ou de résorption osseuse liée à un état pathologique en règle générale, y compris mais pas seulement les maladies suivantes : ostéoporose, arthrite, polyarthrite rhumatoïde, métastases osseuses du cancer, cancer des os, hypercalcémie, lésions ostéolytiques avec implants orthopédiques, maladie de Paget, et perte osseuse associée à l'hyperparathyroïdisme. On peut citer entre autres comme cancers, sans limitation : cancer du sein, cancer du colon, cancer de la prostate, cancer endométrial, myélome multiple, carcinome des cellules rénales, cancer dans la zone de la nuque et du cou, et carcinome du col. Parmi les affections arthritiques, on citera entre autres, mais sans limitation : arthrite induite par adjuvant, collagène, bactérie et antigène, en particulier polyarthrite rhumatoïde.

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