C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 305/14 (2006.01) A61K 31/185 (2006.01) A61K 31/201 (2006.01) C07C 305/06 (2006.01) C07C 305/10 (2006.01) C12N 9/14 (2006.01) C12N 9/99 (2006.01)
Patent
CA 2618827
Inhibitors of the phosphatase activity of soluble epoxide hydrolase (sEH) are provided and are useful for in the treatment of diseases. These Inhibitors are based on derivatives of various epoxide hydrolase substrates that mimic the enzyme substrate so that there Is stable Interaction with the enzyme catalytic site. These inhibitors are potentially useful for the treatment of hypertension, vascular inflammation, renal inflammation, and lung disease.
La présente invention décrit des inhibiteurs de l'activité phosphatase d'une époxyde hydrolase soluble (sEH) pouvant être employés dans le traitement de maladies. Ces inhibiteurs sont à base de dérivés de divers substrats d'époxyde hydrolase qui imitent le substrat enzymatique de sorte qu'il y ait une interaction stable avec le site catalytique de l'enzyme. Ces inhibiteurs sont potentiellement utiles dans le traitement de l'hypertension, de l'inflammation vasculaire, de l'inflammation rénale, et de maladie pulmonaire.
Hammock Bruce D.
Morisseau Christophe
Newman John W.
Fetherstonhaugh & Co.
The Regents Of The University Of California
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