C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) A61K 31/355 (2006.01) A61K 31/4709 (2006.01) A61K 31/519 (2006.01) A61K 31/5365 (2006.01) A61K 31/5375 (2006.01) A61P 7/02 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2495661
The present invention relates to selective inhibitors of phosphoinositide (PI) 3-kinase .beta., use of the selective inhibitors in anti-thrombotic therapy, and a method for screening compounds useful for the new anti-thrombotic therapy by detecting selective inhibitory activity of PI 3-kinase .beta. of the compound. The invention also relates to novel compounds of formula II that are inhibitors of PI 3-kinase. (see formula I)
La présente invention se rapporte à des inhibiteurs sélectifs de la phosphoinositide (PI) 3-kinase .szlig., à l'utilisation desdits inhibiteurs sélectifs en thérapeutique anti-thrombotique, et à un procédé de criblage de composés utiles à la nouvelle thérapeutique anti-thrombotique, ledit procédé faisant appel à la détection de l'activité inhibitrice sélective de la PI 3-kinase .szlig. du composé. L'invention concerne également de nouveaux composés qui sont des inhibiteurs de la PI 3-kinase .szlig..
Abbott Belinda
Anderson Karen
Goncalves Isaac
Jackson Shaun P.
Kenche Vijaya
Astrazeneca Ab
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Kinacia Pty Ltd.
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