Inhibition of protein kinase c by long-chain bases

Details Inhibition of protein kinase c by long-chain bases Inhibition of protein kinase c by long-chain bases

A - Human Necessities

61

K

167/199, 167/250

A61K 31/70 (2006.01) A61K 31/66 (2006.01) C07H 15/04 (2006.01) C07H 15/10 (2006.01)

Patent

CA 1307466

Inhibition of Protein Kinase C by Long-Chain Bases Abstract Compositions for inhibiting protein kinase C, comprising an inhibitory amount of a compound having the formula: Image wherein Q is a hydrophobic group; wherein X is -CH2-CH2- Or -CH=CH-, which may be substituted by one or more halogens or C1-C3 alkyl groups, wherein Y is Image , Image , Image , -CH2-, or Image , wherein W is a halogen; wherein R1 and R2 may be the same or different and are selected from hydrogen, lower alkyl groups having from 1 to 7 carbon atoms, aralkyl, and aryl groups, and wherein Z is a phosphate or an organic group, and a pharmaceutically acceptable carrier material; and a method for inhibiting protein kinase C using such compositions.

546783

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