C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/48 (2006.01) A01K 67/027 (2006.01) A61K 31/00 (2006.01) A61K 31/05 (2006.01) A61K 31/404 (2006.01) A61K 31/4045 (2006.01) A61K 31/713 (2006.01) A61K 38/00 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 49/00 (2006.01) A61P 9/04 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2526423
The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2 and Class II HDACs has been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of class II HDAC~s has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides the link between MEF-2 and class II HDAC~s, a kinase known as PKD. The present invention further demonstrates that inhibitors of PKD inhibit cardiac hypertrophy and heart disease by inhibiting, in part, the fetal cardiac gene expression and cellular reorganization that occurs when MEF-2 dependent transcription is inhibited.
La présente invention porte sur des méthodes de traitement et de prévention de l'hypertrophie cardiaque et de l'insuffisance cardiaque. MEF-2 et HDAC de la Classe II s'avèrent avoir un rôle majeur dans l'hypertrophie cardiaque et les maladies cardiaques, et l'inhibition de HDAC de la classe II s'avère avoir un effet anti-hypertrophique bénéfique. La présente invention porte sur la liasion entre MEF-2 et HDAC de la classe II, une kinase connue comme PKD. L'invention apporte la preuve que les inhibiteurs de PKD inhibent l'hypertrophie cardiaque et les maladies cardiaques en inhibant, partiellement, l'expression génique cardiaque foetale et la réorganisation cellulaire survenant lorsque la transcription dépendant de MEF-2 est inhibée.
Mckinsey Timothy A.
Olson Eric
Vega Rick B.
Board Of Regents The University Of Texas System
Goudreau Gage Dubuc
Myogen Inc.
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