A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/551 (2006.01) A01K 67/027 (2006.01) A61K 31/4409 (2006.01) A61P 9/04 (2006.01)
Patent
CA 2555632
The present invention provides for methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2 and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of class II HDAC's has been shown to have a beneficial, anti-hypertrophic effect. The present invention provides a link between MEF-2 and class II HDAC's, a kinase known as PRK. The present invention further demonstrates that inhibitors of PRK inhibit cardiac hypertrophy and heart disease by inhibiting, in part, the fetal cardiac gene expression and cellular reorganization that occurs when MEF-2 dependent transcription is activated.
La présente invention concerne des techniques de traitement de prévention de l'hypertrophie cardiaque et de l'insuffisance cardiaque. MEF-2 et HDAC de classe II ont présentés des effets bénéfiques et anti-hypertrophiques. Cette fin fond de la invention concerne une liaison entre MEF-2 et HDAC de classe II, une kinase connue sous le sigle PRK. Cette invention démontre aussi que des inhibiteurs de PRK inhibent l'hypertrophie cardiaque et une maladie cardiaque par inhibition, d'une part, de l'expression du gène cardiaque foetal et la réorganisation cellulaire qui survient lorsque la transcription dépendante de MEF-2 est activée.
Harrison Brooke
Helmke Steve
Mckinsey Timothy A.
Olson Eric
Rybkin Igor
Bcf Llp
Board Of Regents The University Of Texas System
Myogen Inc.
The Regents Of The University Of Colorado A. Body Corporate
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