Inhibition of protein kinases with piridinylimidazoles

Details Inhibition of protein kinases with piridinylimidazoles Inhibition of protein kinases with piridinylimidazoles

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01) A01K 67/027 (2006.01) A61K 31/44 (2006.01) A61K 31/4439 (2006.01) C12N 9/12 (2006.01) C12Q 1/00 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2327386

a method of inhibiting a protein kinase that has a threonine or less bulky residue at the position equivalent to Thr 106 in SAPK2a/p38, and not mammalian SAPK2a/p38 or SAPK2b/p38.beta.2, is provided, wherein the protein kinase is exposed to a pyridinyl imidazole inhibitor. The protein kinase may be a TGF.beta. type-I or type-II receptor.

L'invention concerne un procédé d'inhibition d'une protéine kinase présentant une thréonine ou un résidu moins volumineux dans la position correspondant à Thr 106 dans SAPK2a/p38, mais qui n'est pas SAPK2a/p38 ou SAPK2b/p38.beta.2 du mammifère. Dans ce procédé, la protéine kinase est exposée à un inhibiteur pyridinyl-imidazole. La protéine kinase peut être un récepteur de TGF.beta. de type I ou de type II.

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