A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/00 (2006.01) A61K 31/438 (2006.01) A61K 31/4515 (2006.01) A61K 31/473 (2006.01) A61K 31/4741 (2006.01) A61K 31/4743 (2006.01) A61K 31/4745 (2006.01) A61K 31/48 (2006.01) A61K 31/496 (2006.01) A61K 31/5415 (2006.01) A61K 31/55 (2006.01)
Patent
CA 2304592
The invention provides methods for inhibiting psychostimulant-induced or nicotine-induced craving of additional psychostimulants (e.g., cocaine or amphetamine) or nicotine. In these methods, D1-like (dopamine receptor) antagonists or agonists selected from the group consisting of SCH-39166, SCH- 23388, SCH-23390, A-69024, bulbocapnine, (+)butaclamol HCI, fluphenazine HCI, cis-(Z)-flupenthixol, fluspirilene, haloperidol, SCH-12679, SKF-83566, thioridazine HCI, thiothixene HCI, trifluoperazine 2HCI, trifluperidol HCI, A- 86929, skf-81297, SKF-38393, R(-)-N-allylnorapomorphine HBr, R-(-)-apomorphine HCI, R-(+)-6-bromo-APB, R-(+)-6-chloro-ABP, (+)-SKF-82958, Pergolide methanesulfonate, and SKF-77434 are administed to a patient dependent on psychostimulant drugs or nicotine and therefore susceptible to, or suffering from, such a craving. Also disclosed is an animal model system useful for measuring the ability of test compounds to inhibit psychostimulant-induced or nicotine-induced cravings in humans.
L'invention concerne des procédés d'inhibition de l'état de besoin induit par les psychostimulants ou la nicotine, se manifestant par un désir impérieux de consommer d'autres psychostimulants (ex. cocaïne ou l'amphétamine) ou de la nicotine. Dans ces méthodes, des antagonistes du type D1 ou des agonistes du type D1 sont administrés à un patient dépendant de psychostimulants ou de la nicotine et sujet audit état de besoin ou souffrant de celui-ci. L'invention porte également sur un système de modèle animal utile pour la mesure de la capacité de composés d'essai à inhiber l'état de besoin induit par les psychostimulants ou la nicotine chez les humains.
Breiter Hans C.
Rosen Bruce R.
Smart & Biggar
The General Hospital Corporation
LandOfFree
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