Inhibition of raf kinase using symmetrical and unsymmetrical...

Details Inhibition of raf kinase using symmetrical and unsymmetrical... Inhibition of raf kinase using symmetrical and unsymmetrical...

C - Chemistry, Metallurgy

07

C

C07C 275/24 (2006.01) A61K 31/17 (2006.01) A61K 31/38 (2006.01) A61K 31/44 (2006.01) C07C 275/36 (2006.01) C07D 213/02 (2006.01) C07D 213/32 (2006.01) C07D 213/40 (2006.01) C07D 213/50 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/69 (2006.01) C07D 213/70 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01) C07D 213/89 (2006.01) C07D 215/20 (2006.01) C07D 239/38 (2006.01) C07D 277/68 (2006.01) C07D 317/64 (2006.01) C07D 333/02 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 409/

Patent

CA 2315646

The invention relates to a compound of formula I: (see formula I) wherein A is (see formula II), (see formula III) or (see formula IV) R3, R4, R5 and R6 are each, independently, H, halogen, NO2, C1-10-alkyl, C1-10-alkoxy, C6-12 aryl, or C5-12 hetaryl of 1-3 rings, and one of R3-R6 can be -X-Y; or two adjacent R3-R6 can together be an aryl or hetaryl ring with 5-12 atoms; R4' , R5' and R6' are independently H; halogen; C1-C10 alkyl, C1-C10 alkoxy or -X-Y, with the proviso that at least one of R4' , R5' or R6' is -X-Y, or that two adjacent of R4' , R5' and R6' together are a hetaryl ring with 5-12 atoms; R3' is H, halogen, C1-C10 alkyl, or C1-C10 alkoxy; X is -CH2-, -S-, -N(CH3)-, -NHC(O)-, -CH2-S-, -S-CH2; -C(O)-, or -O-; and X is additionally a single bond where Y is pyridyl; and Y is phenyl, pyridyl, naphthyl, pyridone, pyrazine, pyrimidine, benzodioxane, benzopyridine, or benzothiazole; or a pharmaceutically acceptable salt thereof, with the proviso that if X is -O- or -S-, R3' and R6' are H, and Y is phenyl unsubstituted by OH, then R6 is alkoxy.

L'invention a trait à l'utilisation d'un groupe d'aryle urées pour traiter des maladies induites par la raf kinase, et à des compositions pharmaceutiques utiles pour ce type de thérapie.

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