A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/198 (2006.01) A61P 39/00 (2006.01)
Patent
CA 2379696
The invention relates to the use of the combination of a first compound which is lysine, or an amino acid or other proteinaceous moiety having a free amino group with a pKa substantially similar or equal to that of lysine, or pharmaceutically ac-ceptable salts or carboxyl derivatives thereof, and a second compound, which is a positively charged compound, or pharmaceutically acceptable salts or carboxyl derivatives thereof, for the preparation of a composition for inhibiting renal uptake of substances, in particular proteins or peptides, that may be damaging to the kidneys, and that are used for therapeutical or diagnostic purposes. The combination consists advantageously of lysine and arginine.
Cette invention concerne l'utilisation d'une combinaison comprenant un premier composé qui consiste en de la lysine ou en un acide aminé ou un autre fragment protéinacé possédant un groupe amino libre avec un pKa globalement similaire ou identique à celui de la lysine, ladite combinaison pouvant encore contenir des sels pharmaceutiquement acceptables ou des dérivés carboxyle de ce composé. Cette combinaison comprend également un second composé qui consiste en un composé à charge positive ou en des sels pharmaceutiquement acceptables ou des dérivés carboxyle de ce composé. Cette composition permet d'inhiber l'absorption rénale de substances, notamment des protéines et des peptides, qui peuvent endommager les reins et qui sont utilisées à des fins diagnostiques ou thérapeutiques. Cette composition se compose avantageusement de lysine et d'arginine.
de Jong Marion
Krenning Eric Paul
Valkema Roelf
Biosynthema Inc.
Fetherstonhaugh & Co.
Mallinckrodt Inc.
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