Inhibition of selectin binding

Details Inhibition of selectin binding Inhibition of selectin binding

A - Human Necessities

61

K

A61K 31/70 (2006.01) A61K 9/127 (2006.01) A61K 47/44 (2006.01) A61K 47/48 (2006.01)

Patent

CA 2247115

This invention provides a system for inhibiting the binding between two cells, one expressing P- or L-selectin on the surface and the other expressing the corresponding ligand. A covalently cross-linked lipid composition is prepared having saccharides and acidic group on separate lipids. The composition is then interposed between the cells so as to inhibit binding. Inhibition can be achieved at an effective oligosaccharide concentration as low as 10 6 fold below that of the free saccharide. Since selectins are involved in recruiting cells to sites of injury, this system can be used to palliate certain inflammatory and immunological conditions.

Cette invention concerne un système d'inhibition de la fixation entre deux cellules, l'une exprimant la sélectine P ou L sur la surface et l'autre exprimant le ligand correspondant. On prépare une composition lipidique, réticulée de manière covalente, qui renferme des saccharides et un groupe acide sur des lipides séparés. Ensuite, on interpose la composition entre les cellules pour inhiber la fixation. L'inhibition peut être obtenue à une concentration en oligosaccharides efficace, 10<6> fois inférieure au saccharide libre. Du fait que les sélectines sont impliquées dans le recrutement des cellules sur des sites de lésions, ce système peut être utilisé pour pallier certains états inflammatoires et immunologiques.

Affiliated with

Also associated with

Rating

Inhibition of selectin binding does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of selectin binding, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of selectin binding will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1371987