A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) A61L 29/16 (2006.01) A61L 31/16 (2006.01) A61P 9/00 (2006.01) C12N 5/02 (2006.01) C12N 9/02 (2006.01) C12N 15/53 (2006.01) A61M 5/30 (2006.01) A61M 25/00 (2006.01) A61M 31/00 (2006.01)
Patent
CA 2343575
The present method provides a method for inhibiting restenosis associated with mechanical injury of a blood vessel. Human heme oxygenase (I) (HO1) is directly administered at the site of injury. The present inventors have discovered that carbon monoxide generated by HO1 is involved in the molecular pathogenesis of vascular proliferative disorders. By using adenoviral-mediated expression of inducible heme oxygenase 1 in primary vascular smooth muscle cells (vsmc) in vivo, the present inventors demonstrate that in vivo expression of HO1 can be used to treat restenosis.
L'invention concerne une méthode permettant d'inhiber la resténose associée à la blessure mécanique d'un vaisseau sanguin. L'hème oxygénase humaine 1 (HO1) est directement administrée sur le site de la blessure. Selon l'invention, on a découvert que le monoxyde de carbone produit par HO1 participe à la pathogénie musculaire de troubles vasculaires proliférants. L'utilisation de l'expression induite par adénovirus de l'hème oxygénase 1 inductible dans des cellules du muscle lisse de la paroi vasculaire in vivo démontre que l'expression in vivo de HO1 peut servir à traiter la resténose.
Nabel Elizabeth G.
Nabel Gary J.
Cassan Maclean
The Regents Of The University Of Michigan
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