A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/403 (2006.01) A61P 9/00 (2006.01)
Patent
CA 2176377
The present invention provides a new medical use of the hydroxycarbazole compounds of Formula (I), preferably the hydroxylated metabolites of 1- (carbazol-4-yloxy-3-[[2-(o-methoxyphenoxy)ethyl]amino]-2-propanol) (carvedilol), for inhibiting the migration and proliferation of smooth muscle cells. In particular, the present invention provides a new use for the hydroxycarbazole compounds of Formula (I) for prevention of restenosis following percutaneous transluminal coronary angioplasty (PTCA), suppression of the progression of vascular hypertrophy associated with hypertension, and prevention of development of atherosclerosis. In formula (I) R1-R9 are independently -H or -OH, with the proviso that at least one of R1-R9 is OH.
La présente invention se rapporte à une nouvelle utilisation dans le domaine médical des composés d'hydroxycarbazole de la formule (I), de préférence les métabolites hydroxylés de 1-(carbazol-4-yloxy-3-[[2-(o-méthylphénoxy)éthyl]amino]-2-propanol) (carvedilol), qui inhibent la migration et la prolifération des cellules musculaires lisses. La présente invention concerne notamment une nouvelle utilisation des composés d'hydroxycarbazole de la formule (I) dans la prévention de la resténose pouvant apparaître après une cononarographie transluminale percutanée (CTP), l'interruption de l'évolution de l'hypertrophie vasculaire associée à l'hypertension, et la prévention de l'athérosclérose; formule (I) dans laquelle R¿1?-R¿9? représentent indépendamment -H ou -OH à condition qu'au moins l'un des R¿1?-R¿9? représente OH.
Feuerstein Giora Z.
Ohlstein Eliot H.
Yue Tian-Li
Boehringer Mannheim Pharmaceuticals Corp. - Smithkline Beecham C
Gowling Lafleur Henderson Llp
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