A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/711 (2006.01) A61K 39/395 (2006.01) A61P 25/00 (2006.01) C07H 21/00 (2006.01) C12N 15/12 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2667582
A method of treating a pathophysiological condition caused by the production of growth-inhibiting proteoglycans is provided. It is based on the finding that down-regulation of SOX9 results in decreased production of growth-inhibiting factors such as proteoglycans, and increased production of growth-promoting factors such as a laminin and fibronectin. The method of the present invention comprises the inhibition of SOX9 expression and function with an inhibitor such as an antisense oligonucleotide or a siRNA.
L'invention concerne un procédé de traitement d'un état pathophysiologique provoqué par la production de protéoglycanes inhibant la croissance. Elle est basée sur la découverte d'après laquelle une régulation négative de SOX9 conduit à une production diminuée de facteurs inhibant la croissance, tels que les protéoglycanes, et à une production augmentée de facteurs favorisant la croissance tels que la laminine et la fibronectine. Le procédé de la présente invention comprend l'inhibition de l'expression et de la fonction de SOX9 par un inhibiteur tel qu'un oligonucléotide anti-sens ou un ARNsi.
Brown Arthur
Gris Paul
Gowling Lafleur Henderson Llp
The University Of Western Ontario
LandOfFree
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