Inhibition of specific histone deacetylase isoforms

Details Inhibition of specific histone deacetylase isoforms Inhibition of specific histone deacetylase isoforms

C - Chemistry, Metallurgy

12

N

C12N 15/55 (2006.01) A61K 31/18 (2006.01) A61K 31/4035 (2006.01) A61K 31/4418 (2006.01) A61K 31/7088 (2006.01) A61K 31/711 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07C 237/20 (2006.01) C07C 311/21 (2006.01) C07H 21/00 (2006.01) C12N 9/18 (2006.01) C12N 15/11 (2006.01) C12Q 1/44 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408385

This invention relates to the inhibition of histone deacetylase expression and enzymatic activity. The invention provides methods and reagents for inhibiting specific histone deacetylase (HDAC) isoforms by inhibiting expression at the nucleic acid level or enzymatic activity at the protein level.

L'invention concerne l'inhibition de l'expression de l'histone déacétylase et de l'activité enzymatique. L'invention concerne des méthode et des réactifs servant à inhiber des isoformes spécifiques d'histone déacétylase (HDAC) en inhibant l'expression au niveau de l'acide nucléique ou l'activité enzymatique au niveau des protéines.

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