A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) A61K 31/202 (2006.01) A61K 31/426 (2006.01) A61K 31/427 (2006.01) A61K 31/439 (2006.01) A61K 31/4439 (2006.01) C12N 9/02 (2006.01)
Patent
CA 2493584
It is disclosed here that insulin sensitivity in a human or non-human animal can be increased by reducing stearoyl-CoA desaturase-1 (SCD 1) activity in the animal. This provides a new tool for treating and preventing type 2 diabetes. Also disclosed are methods for identifying agents that can increase insulin sensitivity in a human or non-human animal through determining the agents' effects on SCD1 activity.
L'invention concerne la possibilité d'augmenter la sensibilité à l'insuline chez un être humain ou un animal par le biais de la diminution de l'activité du gène stéaroyl-CoA désaturase-1 (SCD 1). Cette invention a trait à un nouvel outil permettant de traiter et de prévenir les diabètes de type 2, ainsi qu'à des méthodes d'identification d'agents qui peuvent accroître la sensibilité à l'insuline chez un être humain ou un animal par détermination des effets des agents sur l'activité SCD1.
Attie Alan D.
Miyazaki Makoto
Ntambi James M.
Gowling Lafleur Henderson Llp
Wisconsin Alumni Research Foundation
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