Inhibition of stress activated protein kinase (sapk) pathway...

Details Inhibition of stress activated protein kinase (sapk) pathway... Inhibition of stress activated protein kinase (sapk) pathway...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) C07K 14/82 (2006.01) C12N 9/12 (2006.01) C12N 15/11 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2291451

The present invention provides compositions that can be administered to an individual and inhibit a stress activated protein kinase pathway. The invention also provides methods of increasing the sensitivity of cancer cells to a cancer therapy by contacting the cancer cells with a stress activated protein kinase pathway inhibitor. The invention further provides methods of reducing the severity of a cancer in a patient by administering to the patient a stress activated protein kinase pathway inhibitor and treating the patient with a conventional cancer therapy.

Cette invention concerne des compositions qui peuvent être administrées à un individu et qui inhibent une voie de la protéine kinase activée par le stress. Cette invention concerne également des procédés permettant d'augmenter la sensibilité de cellules cancéreuses à une thérapie anticancéreuse, ces procédés consistant à mettre en contact les cellules cancéreuses avec un inhibiteur de la voie de la protéine kinase activée par le stress. Cette invention concerne également des procédés permettant de réduire la gravité d'un cancer chez un patient, ces procédés consistant à administrer au patient un inhibiteur de la voie de la protéine kinase activée par le stress et à traiter le patient avec une thérapie anticancéreuse classique.

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