Inhibition of tau-tau-association

Details Inhibition of tau-tau-association Inhibition of tau-tau-association

A - Human Necessities

61

K

A61K 31/5415 (2006.01) A61P 25/00 (2006.01) A61P 25/28 (2006.01)

Patent

CA 2633573

The present invention relates to novel methods for the detection of substances capable of modulating or inhibiting pathological tau-tau protein association and pathological neurofilament aggregation. The methods of the present invention are particularly useful in screening substances for the prophylaxis and treatment of Alzheimer's disease, motor neuron disease, Lewy body disease, Pick's disease and progressive supranuclear palsy. In addition, substances capable of selectively inhibiting pathological aggregates while preserving normal cytoskeletal function are described.

La présente invention concerne de nouvelles méthodes de détection de substances capables de moduler ou d'inhiber l'association protéique pathologique tau-tau et l'agrégation pathologique de neurofilaments. Les méthodes décrites dans la présente invention sont particulièrement utiles pour cribler des substances utilisées pour la prévention et le traitement de la maladie d'Alzheimer, des maladies des motoneurones, de la maladie à corps de Lewy, de la maladie de Pick et de la paralysie supranucléaire progressive. Sont également décrites des substances capables d'inhiber sélectivement des agrégats pathologiques tout en préservant la fonction cytosquelettique normale.

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