Inhibition of the formation or activity of human leukocyte...

Details Inhibition of the formation or activity of human leukocyte... Inhibition of the formation or activity of human leukocyte...

C - Chemistry, Metallurgy

12

N

C12N 9/02 (2006.01) A61K 31/00 (2006.01) A61K 31/045 (2006.01) A61K 31/05 (2006.01) A61K 31/155 (2006.01) A61K 31/195 (2006.01) A61K 31/20 (2006.01) A61K 31/35 (2006.01) A61K 31/44 (2006.01) A61K 31/575 (2006.01) A61K 38/08 (2006.01) C07H 21/02 (2006.01) C12N 5/00 (2006.01) C12N 15/53 (2006.01) G01N 33/573 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2077461

The discovery of a new form of 12-lipoxygenase RNA and protein in human adrenal, mononuclear, vascular smooth muscle and endothelial cells is disclosed. Activation of this 12-LO pathway mediates angiotensin II and glucose induced vascular and renal actions. A rationale for the development of pharmaceutical or molecular methods to inhibit this newly discovered lipoxygenase pathway is described.

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