Inhibition of the renin-angiotensin system for the treatment...

A - Human Necessities – 61 – K

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A61K 31/401 (2006.01) A61K 31/4184 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01) A61P 17/00 (2006.01) A61P 19/02 (2006.01)

Patent

CA 2616150

A method of treating a disease or condition in which up-regulating GAGs is therapeutically beneficial is disclosed, in particular osteoarthritis and skin diseases. The method comprises locally administering to a subject a therapeutically effective amount of an agent capable of down-regulating activity or expression of a component of the renin-angiotensin system.

La présente invention concerne une technique de traitement d'une maladie ou d'un état dans lequel les GAG de régulation à la hausse sont thérapeutiquement intéressants. Cette technique consiste administrer localement à un sujet une quantité thérapeutiquement efficace d'un agent capable de réguler à la baisse l'activité ou l'expression d'un composant du système rénine-angiotensine.

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