C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/78 (2006.01) A61K 38/50 (2006.01) A61P 31/14 (2006.01) A61P 31/18 (2006.01)
Patent
CA 2467312
The present invention generally relates to the field of antiviral therapy. More specifically, the present invention relates to the inhibition of the tRNA lys3-primed initiation of reverse transcription in viruses by APOBEC3G. The present invention further relates to a method of treating or preventing viral infections by inhibiting tRNA Lys3 annealing and/or priming on a viral genome thereby reducing viral replication. More particularly, the present invention relates to the use of APOBEC3G, fragments or derivatives thereof for treatment or prophylaxis of HIV-1 infection and related lentivirus infections.
Cen Shan
Guo Fei
Kleiman Lawrence
Cen Shan
Goudreau Gage Dubuc
Guo Fei
Kleiman Lawrence
University Mcgill
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