Inhibition of trp channels as a treatment for cardiac...

Details Inhibition of trp channels as a treatment for cardiac... Inhibition of trp channels as a treatment for cardiac...

A - Human Necessities

61

P

A61P 9/00 (2006.01)

Patent

CA 2545944

The present invention provides methods of treating and preventing cardiac hypertrophy and heart failure. MEF-2, NF-AT3, calcineurin, MCIP, and Class II HDACs have been shown to have a major role in cardiac hypertrophy and heart disease, and inhibition of many of these factors or the pathways mediated by these factors has been shown to have a beneficial, anti -hypertrophic effect. The present invention provides a link between these factors and the pathways they mediate through a family of non-voltage gated channels called TRP channels. The present invention further demonstrates that inhibitors of TRP channels can inhibit or treat heart failure and cardiac hypertrophy.

L'invention concerne des procédés de traitement et de prévention de l'hypertrophie et de l'insuffisance cardiaques. Les MEF-2, NF-AT3, la calcineurine, le MCIP, et les HDAC classe II ont montré qu'ils possédaient un rôle majeur dans l'hypertrophie et l'insuffisance cardiaques et l'inhibition de ces divers facteurs ou passages induits par ces facteurs ont démontré un effet bénéfique, antihypertrophique. L'invention concerne également une liaison entre ces facteurs et les passages qui les induisent à travers une famille de canaux commandés sans tension appelés canaux TRP. Cette invention concerne enfin les inhibiteurs de canaux TRP qui permettent d'inhiber ou de traiter l'insuffisance et l'hypertrophie cardiaques.

Affiliated with

Also associated with

Rating

Inhibition of trp channels as a treatment for cardiac... does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Inhibition of trp channels as a treatment for cardiac..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Inhibition of trp channels as a treatment for cardiac... will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2042757