A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/00 (2006.01) A61K 35/12 (2006.01) C07K 14/47 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2107537
The present invention is directed to a method of inhibiting tumor cell growth. Tumor cells from a pateint are recombinantly engineered to express the B7 surface protein and these cells are then readminsistered to the pateint. The presence of the B7 molecule on the tumor cell surface stimulates a broad immunologic response against both the B7-transfected and non-transfected tumor cells and results in the immunologic killing of localized and metastatic tumor cells. B7 transfection of the tumor cells, or cell membranes, serves as a stimulant to engender a potent immunologic response against the surface antigens present on the tumor cells.
Chen Lieping
Hellstrom Ingegerd
Hellstrom Karl E.
Ledbetter Jeffrey A.
Linsley Peter S.
Bristol-Myers Squibb Company
Cassan Maclean
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