A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/17 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2595669
The present invention relates to novel therapies for cancer and, in particular, to therapies that are particularly suited to tumor cells resistant to other types of therapies, such as radiation therapy, chemotherapy, or a combinations thereof. The invention provides methods for identifying and implementing strategies to inhibit a transcription factor involved in promoting resistance and inhibition of apopotosis. The invention provides a compound that alters ATF2 activity, specfically amino-terminal fragments of ATF2 that retain the JNK binding domain. The invention provides methods for inhibiting tumor cell growth and for sensitizing tumor cells to apoptosis with such peptides.
La présente invention a pour objet de nouvelles thérapies contre le cancer, notamment des thérapies qui sont plus particulièrement adaptées à des cellules tumorales résistant à d~autres types de thérapies, telles que la radiothérapie, la chimiothérapie, ou des combinaisons de ces thérapies. La présente invention décrit des méthodes d~identification et de mise en AEuvre de stratégies permettant l'inhibition d'un facteur de transcription impliqué dans la résistance à l'apoptose ou l'inhibition de l~apoptose. La présente invention décrit ainsi un composé qui altère l'activité de l'ATF2, plus particulièrement les fragments N-terminaux de l~ATF2 qui comportent le domaine de liaison de JNK. La présente invention décrit également des méthodes d~inhibition de la croissance de cellules tumorales, ainsi que des méthodes de sensibilisation de cellules tumorales à l~apoptose, à l~aide de tels peptides.
Bhoumik Anindita
Ronai Ze'ev
Mount Sinai School Of Medicine Of New York University
Robic
LandOfFree
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