Inhibition of tumor growth by blockade of the protein c system

Details Inhibition of tumor growth by blockade of the protein c system Inhibition of tumor growth by blockade of the protein c system

A - Human Necessities

61

K

A61K 39/395 (2006.01) A61K 38/17 (2006.01) A61K 38/19 (2006.01) A61K 38/48 (2006.01) C07K 14/47 (2006.01) C07K 14/745 (2006.01) C07K 16/36 (2006.01) C07K 16/40 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2064585

Composition, and methods of use thereof, for the inhibition of tumor growth and killing of tumors having extensive microcirculation wherein the active agent is a compound blocking the protein C system, preferably anti-protein C antibody, anti-protein S antibody and C4b binding protein. In the most preferred embodiment, the protein C blocking compound is provided in combination with a cytokine such as tumor necrosis factor (TNF), gamma interferon, interleukin-1, interleukin-2 and granulo-cytemacrophage colony stimulating factor. Example are provided demonstrating the administration of the protein C blocking compound, alone or in combination with TNF, to dogs having canine venereal tumors, a fibrosarcoma, and an adenocarcinoma, to pigs with melanoma, and a primate with a malignant lymphoma, followed by significant tumor reduction.

Des compositions et leurs procédés d'utilisation permettent d'inhiber la croissance tumorale et de détruire des tumeurs a microcirculation étendue. L'agent actif est un composé qui bloque le système de protéine C, de préférence un anticorps de l'anti-protéine C, un anticorps de l'anti-protéine S et une protéine de liaison de C4b. Dans le mode préférentiel de réalisation, le composé de blocage de la protéine C est associé à une cytokine telle que le facteur de nécrose de tumeurs (TNF), l'interféron gamma, l'interleucine-1, l'interleucine-2 et le facteur de stimulation des colonies de granulocytes-macrophages. On décrit des exemples d'administration du composé de blocage de la protéine C, que ce soit isolément ou en association avec TNF, à des chiens ayant des tumeurs vénériennes canines, un fibrosarcome, et un adénocarcinome, à des cochons ayant des mélanomes, et à un primate avec un lymphome malin, l'administration du composé ayant été suivie d'une réduction significative des tumeurs.

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