Inhibition of tumor necrosis factor alpha

A - Human Necessities – 61 – K

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Details

A61K 31/44 (2006.01) A61K 31/4412 (2006.01) A61K 31/4418 (2006.01) A61K 31/4436 (2006.01) A61K 31/4439 (2006.01) A61K 31/444 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01)

Patent

CA 2232191

In a preferred embodiment, a method for the inhibition of the synthesis and release of tumor necrosis factor from various cells, comprising: administering to a human or other mammal an effective dose of one or more pharmaceutical substances selected from the group consisting of N-substituted 2(1H) pyridones, N-substituted 3(1H) pyridones, and pharmaceutically acceptable salts thereof.

La présente invention concerne, selon une réalisation préférée, un procédé d'inhibition de la synthèse et de la libération du facteur .alpha. de nécrose tumorale par différentes cellules. Ce procédé consiste à administrer à l'homme ou un autre mammifère une dose efficace constituée d'une ou de plusieurs substances pharmaceutiques appartenant au groupe des pyridones 2(1H) N-substitués, des pyridones 3(1H) N-substitués et de leurs sels pharmaceutiquement admis.

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