Inhibition of urokinase-type plasminogen activator (upa)...

Details Inhibition of urokinase-type plasminogen activator (upa)... Inhibition of urokinase-type plasminogen activator (upa)...

A - Human Necessities

61

K

A61K 38/19 (2006.01) A61P 35/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/566 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2703184

The invention concerns methods for inhibiting the binding of urokinase-type plasminogen activator (uPA) to its receptor uPAR and/or inhibiting uPA biological activity. The invention further concerns methods for inhibiting tumor formation or metastasis, angiogenesis, such as tumor angiogenesis, and screening assays for identifying CYTL1 agonists.

Les procédés de l'invention permettent d'inhiber la liaison de l'activateur du plasminogène de type urokinase (uPA) à son récepteur uPAR et/ou d'inhiber l'activité biologique de l'uPA. Cette invention concerne, en outre, des procédés permettant d'inhiber la formation de tumeur ou la métastase, l'angiogenèse, telle que l'angiogenèse tumorale, et des dosages de type criblage pour identifier des agonistes CYTL1.

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