Inhibition of viral gene expression using small interfering rna

Details Inhibition of viral gene expression using small interfering rna Inhibition of viral gene expression using small interfering rna

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A61K 31/713 (2006.01) A61P 31/14 (2006.01)

Patent

CA 2622242

The invention provides methods, compositions, and kits comprising small interfering RNA (shRNA or siRNA) that are useful for inhibition of viral- mediated gene expression. Small interfering RNAs as described herein can be used in methods of treatment of HCV infection. ShRNA and siRNA constructs targetING the internal ribosome entry site (IRES) sequence of HCV are described.

L'invention concerne des méthodes, des compositions et des kits renfermant un petit ARN interférent (RNAsh ou RNAsi) lesquels sont utiles dans l'inhibition de l'expression génique à médiation virale. Les petits ARN interférent ici décrits peuvent être utilisés dans des méthodes de traitement d'infections à virus de l'hépatite C VHC. Des constructions ARNSh et ARNSi ciblant la séquence du site d'entrée de ribosome interne (IRES) du VHC sont décrites.

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