Inhibition of viral infection using monovalent...

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/13 (2006.01) A61K 39/42 (2006.01) A61P 31/12 (2006.01) C07K 16/08 (2006.01) C12N 1/19 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) C12N 15/81 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2370351

A method of inhibiting viral infection using a monovalent antigen binding protein comprising a single domain binding unit capable of binding to a virus is described. Preferably the protein is a heavy chain variable domain derived from an immunoglobulin naturally devoid of light chains. Food, pharmaceutical and cosmetic products comprising such proteins are also described together with a method for selecting inhibiting proteins from a large population of mainly containing non-inhibiting, but infectious agent binding fragments.

L'invention porte sur une méthode d'inhibition d'une infection virale au moyen de protéines de liaison à l'antigène monovalentes comprenant une unité de liaison à domaine unique capable de se lier à un virus. De préférence, la protéine comporte un domaine variable à chaîne lourde dérivé d'une immunoglobuline naturellement dépourvue de chaînes légères. Des produits alimentaires, pharmaceutiques et cosmétiques comprenant ces protéines sont également décrits, ainsi qu'une méthode de sélection des protéines inhibitrices dans une grande population principalement composée de fragments de liaison à des agents infectieux, non-inhibiteurs.

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