A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/06 (2006.01) A61K 31/165 (2006.01) A61K 31/195 (2006.01) A61K 31/28 (2006.01) A61K 31/36 (2006.01) A61K 31/41 (2006.01) A61K 31/555 (2006.01)
Patent
CA 2126465
An inhibitor for restenosis after percutaneous coronary arterioplasty (PTCA) which comprises, as an active ingredient, a compound of the following formula (1), (1') or a pharmaceutically acceptable salt thereof: (see formulas) wherein R1 and R2 are independently a hydrogen atom, a halogen atom, a trifluoromethyl group, a nitro group, a C1- C6 alkyl group or a C1-C6 alkoxyl group, and R1 and R2 may be linked to form a methylenedioxy group; R3 is an optionally substituted aryl group, an optionally substituted aromatic heterocyclic group, an optionally substituted 5 to 7-membered cycloalkyl or cycloalkenyl group; R4 is a hydrogen atom, a hydroxyl group, an -S-glutathione residue, an -S- a -amino acid residue, or an aralkyl group optionally having substituent(s) in the aryl moiety; R5 is a hydrogen atom or a C1-C6 alkyl group, and R4 and R5 may be linked to form a single bonds Y is an oxygen atom or a sulfur atom; n is an integer of from 0 to 5, and the selenium atom may be oxidized. The inhibitor of the present invention exhibits excellent inhibitory effect against restenosis after PTCA with low toxicity
Hirayama Atsushi
Kodama Kazuhisa
Masayasu Hiroyuki
Daiichi Pharmaceutical Co. Ltd.
Gowling Lafleur Henderson Llp
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