Inhibitor of analgesic tolerance

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/519 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/506 (2006.01) A61K 31/52 (2006.01) A61K 31/522 (2006.01) A61K 45/00 (2006.01) C07D 417/14 (2006.01) C07D 473/06 (2006.01) C07D 473/34 (2006.01) C07D 487/04 (2006.01) C07D 487/14 (2006.01) C07D 495/04 (2006.01)

Patent

CA 2726198

Provided are: an agent for suppressing an undesirable effect of an opioid type analgesic (opioid), which comprises a compound having adenosine A2A receptor antagonistic activity or a pharmaceutically acceptable salt thereof as an active ingredient; the agent for suppressing an undesirable effect of an opioid type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance or constipation; the agent for suppressing an undesirable effect of an opioid-type analgesic (opioid), wherein the undesirable effect of the opioid-type analgesic (opioid) is analgesic tolerance; and the like.

La présente invention concerne un agent destiné à inhiber une activité indésirable d'un agent analgésique de type opioïde (opioïde) qui comprend un composé possédant une activité antagoniste sur un récepteur de l'adénosine A2A ou l'un de ses sels pharmaceutiquement acceptables en tant que principe actif. L'activité indésirable de l'agent analgésique de type opioïde (opioïde) peut être une tolérance aux analgésiques ou une constipation. L'activité indésirable de l'agent analgésique de type opioïde (opioïde) peut être une tolérance aux analgésiques.

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