C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/70 (2006.01) C07K 14/47 (2006.01) C12Q 1/68 (2006.01)
Patent
CA 2343354
An inhibitor of Brn-3b expression and/or activity is useful in the treatment of breast or ovarian cancer. A method for identifying an inhibitor of Brn-3b expression comprises: (a) providing a test construct comprising a Brn-3b promoter operably linked to a coding sequence; (b) contacting a substance to be tested with the test construct under conditions that would permit the polypeptide encoded by the said coding sequence to be expressed in the absence of the said substance; and (c) determining whether the said substance inhibits the expression of Brn-3b.
La présente invention concerne un inhibiteur de l'expression et/ou de l'activité du Brn-3b, lequel inhibiteur convient particulièrement au traitement du cancer de sein ou du cancer des ovaires. L'invention concerne également un procédé aboutissant à l'identification d'un inhibiteur du Brn-3b. Ce procédé consiste (a) à prendre une construction test comprenant un promoteur du Brn-3b fonctionnellement lié à une séquence codante. Le procédé consiste ensuite (b) à mettre en contact avec la construction test une substance à tester dans les conditions qui permettraient au polypeptide codé par la séquence codante considérée de s'exprimer en l'absence de la substance considérée. Le procédé consiste enfin (c) à déterminer si la substance considérée inhibe l'expression du Brn-3b.
Budhram-Mahadeo Vishwanie
Latchman David Seymour
Ndisang Daniel
Macrae & Co.
University College London
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