A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 48/00 (2006.01) C07H 19/06 (2006.01) C07H 21/00 (2006.01)
Patent
CA 2454147
Zebularine has hypomethylating activity, and can be used to inhibit, reverse, and/or reduce DNA methylation in vivo and in vivo. Methods are provided for treating methylation-linked conditions through the application of 2- pyrimidinone derivatives, such as Zebularine. Compositions, including pharmaceutical compositions, comprising such derivatives are also provided. Also provided are kits for use in inhibiting DNA methylation, which kits include an amount of a 2-pyrimidinone derivative.
La zébularine présente une activité d'hypométhylation et peut être utilisée pour inhiber, inverser, et/ou réduire la méthylation in vivo et in vitro d'ADN. L'invention concerne des procédés permettant de traiter des états associés à la méthylation par l'application de dérivés de 2-pyrimidinone, tels que la zébularine. L'invention concerne également des compositions, notamment des compositions pharmaceutiques, comprenant lesdits dérivés. L'invention concerne en outre des kits destinés à être utilisés pour inhiber la méthylation d'ADN, lesdits kits contenant une certaine quantité de dérivé de 2-pyrimidinone.
Cheng Jonathan
Greer Sheldon B.
Jones Peter A.
Marquez Victor E.
Matsen Cindy B.
Smart & Biggar
The Government Of The United States Of America As Represented By
The State Of Oregon Acting By And Through The State Board Of Hig
University Of Miami
University Of Southern California
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